Open AccessSphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry
Author(s) -
Patrick Niekamp,
Gaelen Guzman,
Hans C. Leier,
Ali Rashidfarrokhi,
Veronica Richina,
Fabian Pott,
Caroline Barisch,
Joost C. M. Holthuis,
Fikadu Tafesse
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03141-20
Subject(s) - mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , host (biology) , biology , biosynthesis , sphingomyelin , immunology , medicine , gene , genetics , pathology , membrane
Mycobacterium tuberculosis ( Mtb ) invades alveolar macrophages through phagocytosis to establish infection and cause disease. The molecular mechanisms underlying Mtb entry are still poorly understood.