Open AccessCoxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche
Author(s) -
Tatiana M. Clemente,
Rochelle Ratnayake,
Dhritiman Samanta,
Leonardo Augusto,
Paul A. Beare,
Robert A. Heinzen,
Stacey D. Gilk
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03073-21
Subject(s) - coxiella burnetii , q fever , antibiotics , endocarditis , microbiology and biotechnology , infectious disease (medical specialty) , virology , immunology , disease , medicine , biology
Coxiella burnetii is the causative agent of human Q fever, an emerging infectious disease and significant cause of culture-negative endocarditis. Acute infections are often undiagnosed, there are no licensed vaccines in the United States, and chronic Q fever requires a prolonged antibiotic treatment.