Open AccessMerkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network
Author(s) -
Bizunesh Abere,
Hongzhao Zhou,
Jinghui Li,
Simon Cao,
Tuna Toptan,
Adam Grundhoff,
Nicole Fischer,
Patrick S. Moore,
Yuan Chang
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03059-20
Subject(s) - biology , circular rna , microrna , rna , merkel cell polyomavirus , non coding rna , gene , rnase p , genetics , microbiology and biotechnology , merkel cell carcinoma , carcinoma
Covalently closed circular RNAs were recently described in the human DNA tumor viruses Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated herpesvirus (KSHV), and human papillomavirus (HPV). Here, we show that MCV, another DNA tumor virus, generates circRNAs from its early regulatory region in concert with T antigen linear transcripts.