Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network | Zendy

Bizunesh Abere | Zendy; Hongzhao Zhou | Zendy; Jinghui Li | Zendy; Simon Cao | Zendy; Tuna Toptan | Zendy; Adam Grundhoff | Zendy; Nicole Fischer | Zendy; Patrick S. Moore | Zendy; Yuan Chang | Zendy

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Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network

Author(s) -

Bizunesh Abere,

Hongzhao Zhou,

Jinghui Li,

Simon Cao,

Tuna Toptan,

Adam Grundhoff,

Nicole Fischer,

Patrick S. Moore,

Yuan Chang

Publication year - 2020

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.03059-20

Subject(s) - merkel cell polyomavirus , microrna , circular rna , biology , virology , rna , virus , dna , gene , genetics , merkel cell carcinoma , carcinoma

Covalently closed circular RNAs were recently described in the human DNA tumor viruses Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated herpesvirus (KSHV), and human papillomavirus (HPV). Here, we show that MCV, another DNA tumor virus, generates circRNAs from its early regulatory region in concert with T antigen linear transcripts.

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