Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa | Zendy

Malligarjunan Rajavel | Zendy; Vijay Kumar | Zendy; Ha Nguyen | Zendy; Jacob Wyatt | Zendy; Steven H. Marshall | Zendy; Krisztina M. PappWallace | Zendy; Prasad Deshpande | Zendy; Satish Bhavsar | Zendy; Ravindra Yeole | Zendy; Sachin Bhagwat | Zendy; Mahesh Patel | Zendy; Robert A. Bonomo | Zendy; Focco van den Akker | Zendy

Open Access

Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Author(s) -

Malligarjunan Rajavel,

Vijay Kumar,

Ha Nguyen,

Jacob Wyatt,

Steven H. Marshall,

Krisztina M. PappWallace,

Prasad Deshpande,

Satish Bhavsar,

Ravindra Yeole,

Sachin Bhagwat,

Mahesh Patel,

Robert A. Bonomo,

Focco van den Akker

Publication year - 2021

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.03058-20

Subject(s) - penicillin binding proteins , pseudomonas aeruginosa , chemistry , microbiology and biotechnology , escherichia coli , biochemistry , biology , bacteria , gene , genetics

Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.

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