The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism | Zendy

Elisabeth Reithuber | Zendy; Priyanka Nannapaneni | Zendy; Olena Rzhepishevska | Zendy; Anders E. G. Lindgren | Zendy; Oleksandr Ilchenko | Zendy; Staffan Normark | Zendy; Fredrik Almqvist | Zendy; Birgitta HenriquesNormark | Zendy; Peter Mellroth | Zendy

Open Access

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism

Author(s) -

Elisabeth Reithuber,

Priyanka Nannapaneni,

Olena Rzhepishevska,

Anders E. G. Lindgren,

Oleksandr Ilchenko,

Staffan Normark,

Fredrik Almqvist,

Birgitta HenriquesNormark,

Peter Mellroth

Publication year - 2020

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.03027-20

Subject(s) - biochemistry , fatty acid , microbiology and biotechnology , polyunsaturated fatty acid , biology , bacteria , streptococcus pneumoniae , chemistry , antibiotics , genetics

Fatty acid biosynthesis is an attractive antibiotic target, as it affects the supply of membrane phospholipid building blocks. In Streptococcus pneumoniae , it is not sufficient to target only the endogenous fatty acid synthesis machinery, as uptake of host fatty acids may bypass this inhibition.

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