Open AccessThe Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism
Author(s) -
Elisabeth Reithuber,
Priyanka Nannapaneni,
Olena Rzhepishevska,
Åsa Lindgren,
О В Ильченко,
Staffan Normark,
Fredrik Almqvist,
Birgitta HenriquesNormark,
Peter Mellroth
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03027-20
Subject(s) - biochemistry , fatty acid , microbiology and biotechnology , polyunsaturated fatty acid , biology , bacteria , streptococcus pneumoniae , chemistry , antibiotics , genetics
Fatty acid biosynthesis is an attractive antibiotic target, as it affects the supply of membrane phospholipid building blocks. In Streptococcus pneumoniae , it is not sufficient to target only the endogenous fatty acid synthesis machinery, as uptake of host fatty acids may bypass this inhibition.