Open AccessMycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion
Author(s) -
B. Izquierdo Lafuente,
Roy Ummels,
Coenraad Kuijl,
Wilbert Bitter,
Alexander Speer
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02983-20
Subject(s) - secretion , mycobacterium tuberculosis , toxin , intracellular , microbiology and biotechnology , anthrax toxin , chemistry , biology , tuberculosis , biochemistry , recombinant dna , medicine , pathology , gene , fusion protein
CpnT, a NAD + glycohydrolase, is the only known toxin that is secreted by Mycobacterium tuberculosis . CpnT is composed of two domains; the C-terminal domain is the toxin, whereas the N-terminal domain is required for secretion.