Open AccessNitrate Is an Environmental Cue in the Gut for Salmonella enterica Serovar Typhimurium Biofilm Dispersal through Curli Repression and Flagellum Activation via Cyclic-di-GMP Signaling
Author(s) -
Amanda L. Miller,
Lauren K. Nicastro,
Shingo Bessho,
Kaitlyn Grando,
Aaron P. White,
Yi Zhang,
Gillian Queisser,
Bettina A. Buttaro,
Çağla Tükel
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02886-21
Subject(s) - biofilm , salmonella enterica , microbiology and biotechnology , biology , salmonella , flagellum , motility , intestinal epithelium , multicellular organism , chemotaxis , pathogen , bacteria , epithelium , receptor , biochemistry , gene , genetics
Recent studies provided important insight into our understanding of the role of c-di-GMP signaling and the regulation of enteric biofilms. Despite an improved understanding of how c-di-GMP signaling regulatesS. Typhimurium biofilms, the processes that affect the intracellular c-di-GMP levels and the formation of multicellular communitiesin vivo during infections remain unknown.