Open AccessConformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication
Author(s) -
Géraldine Vilmen,
Anna C. Smith,
Héctor Cervera Benet,
Rajni Kant Shukla,
Ross C. Larue,
Alon Herschhorn,
Amit Sharma
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02752-21
Subject(s) - virology , simian immunodeficiency virus , human immunodeficiency virus (hiv) , simian , biology , glycoprotein , aids vaccines , rhesus macaque , viral replication , virus , immunodeficiency , viral envelope , immunology , vaccine trial , genetics , immune system
Rhesus macaques are a critical animal model for preclinical testing of HIV-1 vaccine and prevention approaches. However, HIV-1 does not replicate in rhesus macaques, and thus, chimeric simian-human immunodeficiency viruses (SHIVs), which encode HIV-1 envelope glycoproteins (Envs), are used as surrogate challenge viruses to infect rhesus macaques for modeling HIV-1 infection.