Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication | Zendy

Géraldine Vilmen | Zendy; Anna C. Smith | Zendy; Héctor Cervera | Zendy; Rajni Kant Shukla | Zendy; Ross C. Larue | Zendy; Alon Herschhorn | Zendy; Amit Sharma | Zendy

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Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication

Author(s) -

Géraldine Vilmen,

Anna C. Smith,

Héctor Cervera,

Rajni Kant Shukla,

Ross C. Larue,

Alon Herschhorn,

Amit Sharma

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.02752-21

Subject(s) - simian immunodeficiency virus , virology , simian , biology , human immunodeficiency virus (hiv) , glycoprotein , aids vaccines , cercopithecus aethiops , rhesus macaque , viral replication , virus , immunodeficiency , viral envelope , african green monkey , immunology , vaccine trial , genetics , immune system

Rhesus macaques are a critical animal model for preclinical testing of HIV-1 vaccine and prevention approaches. However, HIV-1 does not replicate in rhesus macaques, and thus, chimeric simian-human immunodeficiency viruses (SHIVs), which encode HIV-1 envelope glycoproteins (Envs), are used as surrogate challenge viruses to infect rhesus macaques for modeling HIV-1 infection.

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