Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1 | Zendy

Junfen Xu | Zendy; Habin Liu | Zendy; Yanqin Yang | Zendy; Xiaohong Wang | Zendy; Poching Liu | Zendy; Yang Li | Zendy; Craig Meyers | Zendy; N. Sanjib Banerjee | Zendy; Hsu-Kun Wang | Zendy; Maggie Cam | Zendy; Weiguo Lü | Zendy; Louise T. Chow | Zendy; Xing Xie | Zendy; Jun Zhu | Zendy; ZhiMing Zheng | Zendy

Open Access

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1

Author(s) -

Junfen Xu,

Habin Liu,

Yanqin Yang,

Xiaohong Wang,

Poching Liu,

Yang Li,

Craig Meyers,

N. Sanjib Banerjee,

Hsu-Kun Wang,

Maggie Cam,

Weiguo Lü,

Louise T. Chow,

Xing Xie,

Jun Zhu,

ZhiMing Zheng

Publication year - 2019

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.02687-18

Subject(s) - biology , cervical intraepithelial neoplasia , cervical cancer , carcinogenesis , cancer research , transcriptome , gene expression , gene , cancer , genetics

High-risk HPV infections lead to development of cervical cancer. This study identified the differential expression of 16 novel genes (LY6K, FAM83A, CELSR3, ASF1B, IQGAP3, SEMA3F, CLDN10, MSX1, CXCL5, ASRGL1, ELAVL2, GRB7, KHSRP, NOVA1, PTBP1, and RNASEH2A) in HPV-infected cervical tissue samples and keratinocytes. Eight of these genes (CDKN2A, ELAVL2, GRB7, HSPB1, KHSRP, NOVA1, PTBP1, and RNASEH2A) encode RNA-binding proteins. Further studies indicated that both HPV16 and HPV18 infections lead to the aberrant expression of selected RBP-encoding genes. We found that viral E6 and E7 decrease NOVA1 expression but that E7 increases RNASEH2A expression via E2F1. The altered expression of these genes may be utilized as biomarkers for high-risk (HR)-HPV carcinogenesis and progression.

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