Open AccessAlteration of the Premature tRNA Landscape by Gammaherpesvirus Infection
Author(s) -
Jessica M. Tucker,
Aaron M. Schaller,
Ian M. Willis,
Britt A. Glaunsinger
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02664-20
Subject(s) - transfer rna , biology , gene , rna polymerase iii , rna , gene expression , transcription (linguistics) , t arm , genetics , rna polymerase , linguistics , philosophy
Viral infection can dramatically change the gene expression landscape of the host cell, yet little is known regarding changes in noncoding gene transcription by RNA polymerase III (RNAPIII). Among these are transfer RNAs (tRNAs), which are fundamental in protein translation, yet whose gene regulatory features remain largely undefined in mammalian cells.