Open AccessRestoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
Author(s) -
Brent W. Simpson,
Martin V. Douglass,
M. Stephen Trent
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02624-20
Subject(s) - lipopolysaccharide , bacterial outer membrane , biogenesis , bacteria , antibiotics , gram negative bacteria , microbiology and biotechnology , chemistry , biology , escherichia coli , biochemistry , immunology , genetics , gene
Gram-negative bacteria produce an asymmetric outer membrane (OM) that is particularly impermeant to many antibiotics and characterized by lipopolysaccharide (LPS) exclusively at the cell surface. LPS biogenesis remains an ideal target for therapeutic intervention, as disruption could kill bacteria or increase sensitivity to existing antibiotics.