Open AccessIntracellular Staphylococcus aureus Perturbs the Host Cell Ca 2+ Homeostasis To Promote Cell Death
Author(s) -
Kathrin Stelzner,
Anderson M. Winkler,
Chunguang Liang,
Aziza Boyny,
Carsten P. Ade,
Thomas Dandekar,
Martin Fraunholz,
Thomas Rudel
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02250-20
Subject(s) - intracellular , extracellular , microbiology and biotechnology , intracellular parasite , programmed cell death , biology , staphylococcus aureus , cytosol , apoptosis , bacteria , biochemistry , genetics , enzyme
Despite being regarded as an extracellular bacterium, the pathogen Staphylococcus aureus can invade and survive within human cells. The intracellular niche is considered a hideout from the host immune system and antibiotic treatment and allows bacterial proliferation.