Open AccessIntracellular Density of Wolbachia Is Mediated by Host Autophagy and the Bacterial Cytoplasmic Incompatibility Gene cifB in a Cell Type-Dependent Manner in Drosophila melanogaster
Author(s) -
Mark A. Deehan,
Weiwei Lin,
Benjamin Blum,
Andrew Emili,
Horácio M. Frydman
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02205-20
Subject(s) - wolbachia , autophagy , drosophila melanogaster , intracellular parasite , obligate , biology , microbiology and biotechnology , intracellular , innate immune system , cytoplasm , cytoplasmic incompatibility , gene , schneider 2 cells , host (biology) , immune system , genetics , rna interference , rna , ecology , apoptosis
Autophagy is a eukaryotic intracellular degradation pathway which can act as an innate immune response to eliminate pathogens. Conversely, pathogens can evolve proteins which modulate the autophagy pathway to subvert degradation and establish an infection. Wolbachia , a vertically transmitted obligate endosymbiont which infects up to 40% of insect species, is negatively regulated by autophagy in whole animals, but the specific molecular mechanism and tissue which govern this interaction remain unknown.