Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains | Zendy

Kentaro Tohma | Zendy; Cara J. Lepore | Zendy; Yamei Gao | Zendy; Lauren A. Ford-Siltz | Zendy; Gabriel I. Parra | Zendy

Open Access

Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

Author(s) -

Kentaro Tohma,

Cara J. Lepore,

Yamei Gao,

Lauren A. Ford-Siltz,

Gabriel I. Parra

Publication year - 2019

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.02202-19

Subject(s) - capsid , biology , epitope , population , genetics , antigen , norovirus , genome , antigenic variation , virology , population genomics , genomics , virus , gene , demography , sociology

Noroviruses are an important cause of viral gastroenteritis around the world. An obstacle delaying the development of norovirus vaccines is inadequate understanding of the role of norovirus diversity in immunity. Using a population genomics approach, we identified new residues on the viral capsid protein (VP1) from GII.4 noroviruses, the predominant genotype, that appear to be involved in the emergence and antigenic topology of GII.4 variants. Careful monitoring of the substitutions in those residues involved in the diversification and emergence of new viruses could help in the early detection of future novel variants with pandemic potential. Therefore, this novel information on the antigenic diversification could facilitate GII.4 norovirus vaccine design.

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