Open Accesslon Deletion Impairs Persister Cell Resuscitation in Escherichia coli
Author(s) -
Sayed Golam Mohiuddin,
Aslan Massahi,
Mehmet A. Orman
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02187-21
Subject(s) - ftsz , multidrug tolerance , escherichia coli , biology , sos response , microbiology and biotechnology , viable but nonculturable , bacteria , cell division , cell , genetics , biofilm , gene
The ATP-dependent Lon protease is one of the most studied bacterial proteases. Although deletion of lon has been frequently shown to reduce fluoroquinolone persistence, the proposed mechanisms underlying this phenomenon are highly controversial.