Open AccessToxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases
Author(s) -
Tatiane S. Lima,
Sharmila Mallya,
Allen Jankeel,
Ilhem Messaoudi,
Melissa B. Lodoen
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02031-20
Subject(s) - toxoplasma gondii , intracellular parasite , obligate , caspase , immune system , apoptosis , biology , microbiology and biotechnology , intracellular , protozoan parasite , cytosol , immunology , parasite hosting , virology , programmed cell death , antibody , genetics , enzyme , ecology , biochemistry , world wide web , computer science
Toxoplasma gondii is an obligate intracellular parasite that can cause life-threatening disease in immunocompromised individuals and in the developing fetus. Interestingly, T. gondii has evolved strategies to successfully manipulate the host immune system to establish a productive infection and evade host defense mechanisms.