Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases | Zendy

Tatiane S. Lima | Zendy; Sharmila Mallya | Zendy; Allen Jankeel | Zendy; Ilhem Messaoudi | Zendy; Melissa B. Lodoen | Zendy

Open Access

Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases

Author(s) -

Tatiane S. Lima,

Sharmila Mallya,

Allen Jankeel,

Ilhem Messaoudi,

Melissa B. Lodoen

Publication year - 2021

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.02031-20

Subject(s) - caspase , apoptosis , blocking (statistics) , toxoplasma gondii , microbiology and biotechnology , cytosol , proliferating cell nuclear antigen , life span , chemistry , programmed cell death , biology , immunology , antibody , biochemistry , enzyme , statistics , immunohistochemistry , mathematics , evolutionary biology

Toxoplasma gondii is an obligate intracellular parasite that can cause life-threatening disease in immunocompromised individuals and in the developing fetus. Interestingly, T. gondii has evolved strategies to successfully manipulate the host immune system to establish a productive infection and evade host defense mechanisms.

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