Open AccessAdvances in Model Systems for Human Cytomegalovirus Latency and Reactivation
Author(s) -
Lindsey B. Crawford,
Nicole L. Diggins,
Patrizia Caposio,
Meaghan H. Hancock
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01724-21
Subject(s) - human cytomegalovirus , latency (audio) , haematopoiesis , progenitor cell , virus , cytomegalovirus , immunology , virology , biology , myeloid , virus latency , herpesviridae , medicine , stem cell , viral disease , viral replication , genetics , computer science , telecommunications
Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ transplant, as well as the leading viral cause of congenital abnormalities. A key feature of the pathogenesis of HCMV is the ability of the virus to establish a latent infection in hematopoietic progenitor and myeloid lineage cells.