Advances in Model Systems for Human Cytomegalovirus Latency and Reactivation | Zendy

Lindsey B. Crawford | Zendy; Nicole L. Diggins | Zendy; Patrizia Caposio | Zendy; Meaghan H. Hancock | Zendy

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Advances in Model Systems for Human Cytomegalovirus Latency and Reactivation

Author(s) -

Lindsey B. Crawford,

Nicole L. Diggins,

Patrizia Caposio,

Meaghan H. Hancock

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.01724-21

Subject(s) - human cytomegalovirus , latency (audio) , haematopoiesis , progenitor cell , virus , cytomegalovirus , virology , immunology , myeloid , biology , herpesviridae , medicine , stem cell , viral disease , genetics , computer science , telecommunications

Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant cause of morbidity and mortality following hematopoietic and solid organ transplant, as well as the leading viral cause of congenital abnormalities. A key feature of the pathogenesis of HCMV is the ability of the virus to establish a latent infection in hematopoietic progenitor and myeloid lineage cells.

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