Open AccessRecovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques
Author(s) -
Kim J. Hasenkrug,
Friederike Feldmann,
Lara Myers,
Mario L. Santiago,
Kejun Guo,
Bradley S. Barrett,
Kaylee L. Mickens,
Aaron B. Carmody,
Atsushi Okumura,
Deepashri Rao,
Madison M. Collins,
Ronald J. Messer,
Jamie Lovaglio,
Carl Shaia,
Rebecca Rosenke,
Neeltje van Doremalen,
Chad S. Clancy,
Greg Saturday,
Patrick W. Hanley,
Brian J Smith,
Kimberly Meade-White,
W. Lesley Shupert,
David W. Hawman,
Heinz Feldmann
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01503-21
Subject(s) - immunology , antibody , immune system , cd8 , virus , virology , t cell , neutralizing antibody , viral load , medicine , titer , coronavirus , biology , disease , covid-19 , infectious disease (medical specialty)
Patients with severe COVID-19 often have decreased numbers of T cells, a cell type important in fighting most viral infections. However, it is not known whether the loss of T cells contributes to severe COVID-19 or is a consequence of it.