Open AccessStep-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants
Author(s) -
Christian Faucher,
Vincent Mazana,
Marion Kardacz,
Nathalie Parthuisot,
JeanBaptiste Ferdy,
David Duneau
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01399-20
Subject(s) - biology , virulence , adaptation (eye) , host (biology) , pathogen , mutation , host adaptation , gene , genetics , immune system , genotype , neuroscience
Within-host evolution has been described in many bacterial diseases, and the genetic basis behind the adaptations has stimulated a lot of interest. Yet, the studied adaptations are generally focused on antibiotic resistance and rarely on the adaptation to the environment given by the host, and the potential trade-offs hindering adaptations to each step of the infection are rarely considered.