Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants | Zendy

Christian Faucher | Zendy; Vincent Mazana | Zendy; Marion Kardacz | Zendy; Nathalie Parthuisot | Zendy; JeanBaptiste Ferdy | Zendy; David Duneau | Zendy

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Step-Specific Adaptation and Trade-Off over the Course of an Infection by GASP Mutation Small Colony Variants

Author(s) -

Christian Faucher,

Vincent Mazana,

Marion Kardacz,

Nathalie Parthuisot,

JeanBaptiste Ferdy,

David Duneau

Publication year - 2021

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.01399-20

Subject(s) - adaptation (eye) , mutation , biology , course (navigation) , computational biology , genetics , virology , computer science , gene , engineering , neuroscience , aerospace engineering

Within-host evolution has been described in many bacterial diseases, and the genetic basis behind the adaptations has stimulated a lot of interest. Yet, the studied adaptations are generally focused on antibiotic resistance and rarely on the adaptation to the environment given by the host, and the potential trade-offs hindering adaptations to each step of the infection are rarely considered.

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