Open AccessA Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol
Author(s) -
Lei Lei,
Chunfu Yang,
Michael J. Patton,
Margery Smelkinson,
David W. Dorward,
Li Ma,
Una Karanovic,
Saba Firdous,
Grant McClarty,
Harlan D. Caldwell
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01179-21
Subject(s) - secretion , virulence , biology , plasmid , microbiology and biotechnology , chlamydia trachomatis , bacterial outer membrane , virulence factor , cytosol , type three secretion system , gene , genetics , virology , biochemistry , escherichia coli , enzyme
TheChlamydia trachomatis plasmid regulates the expression and secretion of immune evasion virulence factors to the host cytosol by an unknown mechanism. In this study, we identified a novel plasmid gene protein 4 (Pgp4)-dependent secretion system.