The Yeast PCNA Unloader Elg1 RFC-Like Complex Plays a Role in Eliciting the DNA Damage Checkpoint | Zendy

Soumitra Sau | Zendy; Batia Liefshitz | Zendy; Martin Kupiec | Zendy

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The Yeast PCNA Unloader Elg1 RFC-Like Complex Plays a Role in Eliciting the DNA Damage Checkpoint

Author(s) -

Soumitra Sau,

Batia Liefshitz,

Martin Kupiec

Publication year - 2019

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.01159-19

Subject(s) - proliferating cell nuclear antigen , dna damage , dna repair , g2 m dna damage checkpoint , dna replication , genome instability , dna re replication , biology , microbiology and biotechnology , dna , genetics , eukaryotic dna replication , cell cycle , cell cycle checkpoint , gene

The Elg1protein forms an RFC-like complex in charge of unloading PCNA from chromatin during DNA replication and repair. Mutations in the ELG1 gene caused genomic instability in all organisms tested and cancer in mammals. Here we show that Elg1 plays a role in the induction of the DNA damage checkpoint, a cellular response to DNA damage. We show that this defect is due to a defect in the signal amplification process during induction. Thus, cells coordinate the cell's response and the PCNA unloading through the activity of Elg1.

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