Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection | Zendy

Florine E. M. Scholte | Zendy; Brian L Hua | Zendy; Jessica R. Spengler | Zendy; John V. Dzimianski | Zendy; JoAnn D. Coleman-McCray | Zendy; Stephen R. Welch | Zendy; Laura K. McMullan | Zendy; Stuart T. Nichol | Zendy; Scott D. Pegan | Zendy; Christina F. Spiropoulou | Zendy; Éric Bergeron | Zendy

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Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

Author(s) -

Florine E. M. Scholte,

Brian L Hua,

Jessica R. Spengler,

John V. Dzimianski,

JoAnn D. Coleman-McCray,

Stephen R. Welch,

Laura K. McMullan,

Stuart T. Nichol,

Scott D. Pegan,

Christina F. Spiropoulou,

Éric Bergeron

Publication year - 2019

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.01065-19

Subject(s) - virology , deubiquitinating enzyme , virus , occupancy , viral infection , crimean–congo hemorrhagic fever , biology , ubiquitin , ecology , biochemistry , gene , tick

Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate that artificially prolonged binding of the OTU to a substrate inhibits virus infection. This provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target.

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