Open AccessStable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection
Author(s) -
Florine E. M. Scholte,
Brian L Hua,
Jessica R. Spengler,
John V. Dzimianski,
JoAnn D. Coleman-McCray,
Stephen R. Welch,
Laura K. McMullan,
Stuart T. Nichol,
Scott D. Pegan,
Christina F. Spiropoulou,
Éric Bergeron
Publication year - 2019
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.01065-19
Subject(s) - virology , deubiquitinating enzyme , virus , occupancy , viral infection , crimean–congo hemorrhagic fever , biology , ubiquitin , ecology , biochemistry , gene , tick
Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate that artificially prolonged binding of the OTU to a substrate inhibits virus infection. This provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target.