Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis | Zendy

Dima A. Hammoud | Zendy; Sanhita Sinharay | Zendy; Swati Shah | Zendy; William Schreiber-Stainthorp | Zendy; Dragan Maric | Zendy; Siva Muthusamy | Zendy; Dianne E. Lee | Zendy; Cheri A. Lee | Zendy; Falguni Basuli | Zendy; William Reid | Zendy; Paul Wakim | Zendy; Kenta Matsuda | Zendy; Vanessa M. Hirsch | Zendy; Avindra Nath | Zendy; Michele Di Mascio | Zendy

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Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis

Author(s) -

Dima A. Hammoud,

Sanhita Sinharay,

Swati Shah,

William Schreiber-Stainthorp,

Dragan Maric,

Siva Muthusamy,

Dianne E. Lee,

Cheri A. Lee,

Falguni Basuli,

William Reid,

Paul Wakim,

Kenta Matsuda,

Vanessa M. Hirsch,

Avindra Nath,

Michele Di Mascio

Publication year - 2019

Publication title -

mbio

Language(s) - English

Resource type - Journals

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00970-19

Subject(s) - simian immunodeficiency virus , cerebrospinal fluid , inflammation , neuroinflammation , immunology , viral encephalitis , macaque , viral load , microglia , immunostaining , encephalitis , virus , virology , medicine , rhesus macaque , pathology , biology , neuroscience , immunohistochemistry

Neurological and cognitive problems are a common complication of HIV infection and are prevalent even in treated individuals. Although the molecular processes underlying brain involvement with HIV are not completely understood, inflammation is suspected to play a significant role. Our work presents anin vivo assessment of neuroinflammation in an animal model of HIV, the simian immunodeficiency virus (SIV)-infected rhesus macaque. Using positron emission tomography (PET) imaging, we identified changes in brain inflammation after inoculation with SIV over time. Interestingly, we found decreased binding of the PET ligand in the presence of very high cerebrospinal fluid (CSF) viral loads. These findings were supported by immunostaining which showed marked glial loss instead of inflammation. This study provides insight into glial and neuronal changes associated with very high CSF viral load and could reflect similar changes occurring in HIV-infected patients.

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