Open AccessBacterial Metal Resistance: Coping with Copper without Cooperativity?
Author(s) -
Nicholas P. Greene,
Vassilis Koronakis
Publication year - 2021
Publication title -
mbio (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00653-21
Subject(s) - efflux , transporter , escherichia coli , bacteria , bacterial cell structure , copper , trimer , chemistry , microbiology and biotechnology , biophysics , cell envelope , biology , biochemistry , dimer , gene , genetics , organic chemistry
InEscherichia coli and other Gram-negative bacteria, tripartite efflux pumps (TEPs) span the entire cell envelope and serve to remove noxious molecules from the cell. CusBCA is a TEP responsible for copper and silver detoxification inE. coli powered by the resistance-nodulation-cell division (RND) transporter, CusA.