Open AccessPlasma Proteomic Analysis Distinguishes Severity Outcomes of Human Ebola Virus Disease
Author(s) -
Arthur Viodé,
Kinga K. Smolen,
Benoit Fatou,
Zainab Wurie,
Patrick van Zalm,
Mandy Kader Kondé,
Balla Moussa Kéita,
Richard Amento Ablam,
Eleanor N. Fish,
Hanno Steen
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00567-22
Subject(s) - ebola virus , proteome , medicine , proteomics , biomarker , laser capture microdissection , disease , blood proteins , viral load , biomarker discovery , virology , immunology , virus , biology , bioinformatics , gene expression , gene , biochemistry
As evidenced by the 2013–2016 outbreak in West Africa, Ebola virus (EBV) disease (EVD) poses a major global health threat. In this study, we characterized the plasma proteomes of 12 individuals infected with EBV, using two different LC-MS-based proteomics platforms and an antibody-based multiplexed cytokine/chemokine assay.