Open AccessIsolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus
Author(s) -
Michael P. Doyle,
Joseph Genualdi,
Adam L. Bailey,
Nurgun Kose,
Christopher Gainza,
Jessica Rodríguez,
Kristen M. Reeder,
Christopher A. Nelson,
Prashant N. Jethva,
Rachel E. Sutton,
Robin Bombardi,
Michael L. Gross,
Justin G. Julander,
Daved H. Fremont,
Michael S. Diamond,
James E. Crowe
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00512-22
Subject(s) - virology , yellow fever , flavivirus , virus , monoclonal antibody , yellow fever vaccine , biology , antibody , antigen , immunology
Yellow fever virus (YFV) is a mosquito-borne virus that occasionally causes outbreaks of severe infection and disease in South America and sub-Saharan Africa. There are very effective live-attenuated (weakened) yellow fever virus vaccines, but recent problems with their production and distribution have left many people in affected areas vulnerable.