Open AccessHistidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics
Author(s) -
Eldar Yagmurov,
Darya Tsibulskaya,
Alexey Livenskyi,
Marina V. Serebryakova,
Yuri I. Wolf,
Sergei Borukhov,
Konstantin Severinov,
Svetlana Dubiley
Publication year - 2020
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00497-20
Subject(s) - antibiotic resistance , histidine , antibiotics , nucleotide , peptide , drug resistance , microbiology and biotechnology , biology , chemistry , enzyme , biochemistry , gene
Uncovering the mechanisms of resistance is a required step for countering the looming antibiotic resistance crisis. In this communication, we show how universally conserved histidine-triad hydrolases provide resistance to microcin C, a potent inhibitor of bacterial protein synthesis.