Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics | Zendy

Eldar Yagmurov | Zendy; Darya Tsibulskaya | Zendy; Alexei Livenskyi | Zendy; Marina V. Serebryakova | Zendy; Yuri I. Wolf | Zendy; Sergei Borukhov | Zendy; Konstantin Severinov | Zendy; Svetlana Dubiley | Zendy

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Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics

Author(s) -

Eldar Yagmurov,

Darya Tsibulskaya,

Alexei Livenskyi,

Marina V. Serebryakova,

Yuri I. Wolf,

Sergei Borukhov,

Konstantin Severinov,

Svetlana Dubiley

Publication year - 2020

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00497-20

Subject(s) - antibiotic resistance , histidine , peptide , antibiotics , nucleotide , drug resistance , microbiology and biotechnology , chemistry , biochemistry , biology , enzyme , gene

Uncovering the mechanisms of resistance is a required step for countering the looming antibiotic resistance crisis. In this communication, we show how universally conserved histidine-triad hydrolases provide resistance to microcin C, a potent inhibitor of bacterial protein synthesis.

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