Open AccessListeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression
Author(s) -
Moran Brenner,
Sivan Friedman,
Adi Haber,
Nurit Livnat-Leva,
Ilya Borovok,
Nadejda Sigal,
Oded Lewinson,
Anat A. Herskovits
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00448-22
Subject(s) - listeria monocytogenes , virulence , cysteine , glutathione , cystine , microbiology and biotechnology , transporter , gene expression , gene , chemistry , virulence factor , biology , biochemistry , bacteria , genetics , enzyme
Bacterial pathogens sense the repertoire of metabolites in the mammalian niche and use this information to shift into the pathogenic state to accomplish a successful infection. Glutathione is a virulence-activating signal that is synthesized byL. monocytogenes during infection of mammalian cells.