Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression | Zendy

Moran Brenner | Zendy; Sivan Friedman | Zendy; Adi Haber | Zendy; Nurit Livnat-Leva | Zendy; Ilya Borovok | Zendy; Nadejda Sigal | Zendy; Oded Lewinson | Zendy; Anat A. Herskovits | Zendy

Open Access

Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression

Author(s) -

Moran Brenner,

Sivan Friedman,

Adi Haber,

Nurit Livnat-Leva,

Ilya Borovok,

Nadejda Sigal,

Oded Lewinson,

Anat A. Herskovits

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00448-22

Subject(s) - listeria monocytogenes , virulence , cysteine , glutathione , cystine , microbiology and biotechnology , transporter , gene expression , gene , chemistry , virulence factor , biology , biochemistry , bacteria , genetics , enzyme

Bacterial pathogens sense the repertoire of metabolites in the mammalian niche and use this information to shift into the pathogenic state to accomplish a successful infection. Glutathione is a virulence-activating signal that is synthesized byL. monocytogenes during infection of mammalian cells.

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