Open AccessAnalysis of mRNA Decay Intermediates in Bacillus subtilis 3′ Exoribonuclease and RNA Helicase Mutant Strains
Author(s) -
Shivani Chhabra,
Zachary F. Mandell,
Bo Liu,
Paul Babitzke,
David H. Bechhofer
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00400-22
Subject(s) - exoribonuclease , polynucleotide phosphorylase , degradosome , rnase p , exosome complex , biology , rnase ph , rna , exonuclease , rna helicase a , genetics , bacillus subtilis , gene , helicase , purine nucleoside phosphorylase , biochemistry , enzyme , purine , bacteria , dna polymerase
The ability to rapidly change bacterial gene expression programs in response to environmental conditions is highly dependent on the efficient turnover of mRNA. While much is known about the regulation of gene expression at the transcriptional and translational levels, much less is known about the intermediate step of mRNA decay.