Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis | Zendy

Giuseppe Cimicata | Zendy; G. Fridkin | Zendy; Tanaya Bose | Zendy; Zohar Eyal | Zendy; Yehuda Halfon | Zendy; Elinor Breiner-Goldstein | Zendy; Tara Fox | Zendy; Ella Zimmerman | Zendy; Anat Bashan | Zendy; Natalia de Val | Zendy; Alexander Wlodawer | Zendy; Ada Yonath | Zendy

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Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis

Author(s) -

Giuseppe Cimicata,

G. Fridkin,

Tanaya Bose,

Zohar Eyal,

Yehuda Halfon,

Elinor Breiner-Goldstein,

Tara Fox,

Ella Zimmerman,

Anat Bashan,

Natalia de Val,

Alexander Wlodawer,

Ada Yonath

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00306-22

Subject(s) - ribosome , eukaryotic ribosome , protein biosynthesis , ribosomal rna , peptidyl transferase , biology , microbiology and biotechnology , rna , helix (gastropod) , biophysics , translation (biology) , ribosomal protein , biochemistry , protein subunit , chemistry , messenger rna , gene , ecology , snail

The mechanism that regulates the translocation step in ribosomes during protein synthesis is not fully understood. In this work, cryo-EM techniques used to image ribosomes fromStaphylococcus aureus after incubation at physiological temperature allowed the identification of a conformation of the helix 68 that has never been observed so far.

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