Open AccessMechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
Author(s) -
Cheng Man Lun,
Abdül Waheed,
Ahlam Majadly,
Nicole D. Powell,
Eric O. Freed
Publication year - 2021
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00219-21
Subject(s) - glycoprotein , viral envelope , microbiology and biotechnology , mechanism (biology) , immune system , viral entry , virology , virus , membrane glycoproteins , mechanism of action , chemistry , biology , viral replication , biochemistry , in vitro , immunology , philosophy , epistemology
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism of action of the MARCH family of cellular proteins that disrupt the trafficking and virion incorporation of viral glycoproteins across several virus families.