Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins | Zendy

Cheng Man Lun | Zendy; Abdul Waheed | Zendy; Ahlam Majadly | Zendy; Nicole Powell | Zendy; Eric O. Freed | Zendy

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Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins

Author(s) -

Cheng Man Lun,

Abdul Waheed,

Ahlam Majadly,

Nicole Powell,

Eric O. Freed

Publication year - 2021

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00219-21

Subject(s) - glycoprotein , viral envelope , viral entry , microbiology and biotechnology , mechanism (biology) , immune system , virology , virus , membrane glycoproteins , mechanism of action , chemistry , biology , viral replication , biochemistry , in vitro , immunology , philosophy , epistemology

Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism of action of the MARCH family of cellular proteins that disrupt the trafficking and virion incorporation of viral glycoproteins across several virus families.

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