A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection | Zendy

Jana Boddin | Zendy; Wing-Hang Ip | Zendy; Britta Wilkens | Zendy; Konstantin von Stromberg | Zendy; Wilhelm Ching | Zendy; Emre Koyuncu | Zendy; Luca D. Bertzbach | Zendy; Thomas Dobner | Zendy

Open Access

A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection

Author(s) -

Jana Boddin,

Wing-Hang Ip,

Britta Wilkens,

Konstantin von Stromberg,

Wilhelm Ching,

Emre Koyuncu,

Luca D. Bertzbach,

Thomas Dobner

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00144-22

Subject(s) - viral replication , biology , adenovirus infection , adenoviridae , virology , mutant , viral vector , gene , viral protein , virus , dna replication , genetic enhancement , microbiology and biotechnology , genetics , recombinant dna

To further understand the biology of human adenoviruses (HAdVs) and to optimize HAdVs for use in prophylactic and therapeutic therapies, a thorough understanding of key viral proteins is paramount. As one of the essential HAdV proteins, the DNA binding protein DBP plays important roles in various steps of the viral replication cycle.

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