Open AccessA Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection
Author(s) -
Jana Boddin,
Wing-Hang Ip,
Britta Wilkens,
Konstantin von Stromberg,
Wilhelm Ching,
Emre Koyuncu,
Luca D. Bertzbach,
Thomas Dobner
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00144-22
Subject(s) - viral replication , biology , adenovirus infection , adenoviridae , mutant , viral vector , virology , gene , virus , viral protein , dna replication , microbiology and biotechnology , genetic enhancement , genetics , recombinant dna
To further understand the biology of human adenoviruses (HAdVs) and to optimize HAdVs for use in prophylactic and therapeutic therapies, a thorough understanding of key viral proteins is paramount. As one of the essential HAdV proteins, the DNA binding protein DBP plays important roles in various steps of the viral replication cycle.