Open AccessA Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress
Author(s) -
Brian M. Wendel,
Huifeng Pi,
Larissa Krüger,
Christina Herzberg,
Jörg Stülke,
John D. Helmann
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.00092-22
Subject(s) - osmotic shock , homeostasis , osmotic concentration , chemistry , cytosol , limiting , potassium , osmotic pressure , magnesium , dehydration , biophysics , osmosis , biocompatible material , biochemistry , microbiology and biotechnology , biology , enzyme , membrane , medicine , organic chemistry , gene , mechanical engineering , engineering , biomedical engineering
Environments with high concentrations of salt or other solutes impose an osmotic stress on cells, ultimately limiting viability by dehydration of the cytosol. A very common cellular response to high osmolarity is to immediately import high levels of potassium ion (K+ ), which helps prevent dehydration and allows time for the import or synthesis of biocompatible solutes that allow a resumption of growth.