Role of MUC5B during Group B Streptococcal Vaginal Colonization | Zendy

Lindsey R. Burcham | Zendy; Jade Bath | Zendy; Caroline A. Werlang | Zendy; Laurie M. Lyon | Zendy; Naoko Liu | Zendy; Christopher M. Evans | Zendy; Katharina Ribbeck | Zendy; Kelly S. Doran | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Role of MUC5B during Group B Streptococcal Vaginal Colonization

Author(s) -

Lindsey R. Burcham,

Jade Bath,

Caroline A. Werlang,

Laurie M. Lyon,

Naoko Liu,

Christopher M. Evans,

Katharina Ribbeck,

Kelly S. Doran

Publication year - 2022

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00039-22

Subject(s) - mucin , group b , glycoprotein , microbiology and biotechnology , streptococcus , group a , colonization , pregnancy , biology , immunology , medicine , bacteria , pathology , genetics

Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group BStreptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infectionin utero. Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterusin vivo .

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research