Open AccessMeasles Virus Induces Functional TRAIL Production by Human Dendritic Cells
Author(s) -
PierreOlivier Vidalain,
Olga Azocar,
Barbara Lamouille,
Anne Astier,
Chantal Rabourdin–Combe,
Christine Servet-Delprat
Publication year - 2000
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.74.1.556-559.2000
Subject(s) - measles virus , biology , virology , virus , morbillivirus , cytotoxic t cell , measles , mononegavirales , immunosuppression , dendritic cell , apoptosis , immunology , immune system , paramyxoviridae , vaccination , in vitro , viral disease , genetics
Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.