Antibody response to respiratory syncytial virus structural proteins in children with acute respiratory syncytial virus infection | Zendy

Raija Vainionpää | Zendy; Olli Meurman | Zendy; Hannu Sarkkinen | Zendy

Open Access

Antibody response to respiratory syncytial virus structural proteins in children with acute respiratory syncytial virus infection

Author(s) -

Raija Vainionpää,

Olli Meurman,

Hannu Sarkkinen

Publication year - 1985

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.53.3.976-979.1985

Subject(s) - biology , virus , virology , immune system , antibody , pneumovirinae , respiratory system , immunology , paramyxoviridae , viral disease , anatomy

The purified respiratory syncytial virus (RSV), Randall strain contained 10 polypeptides (72,000 molecular weight [72K], 66K, 48K, 42K, 40K, 36K, 30K, 23K, 18K, and 15K), 8 of which proved to be virus specific, and polypeptides 48K and 23K were glycosylated. In addition, a high-molecular-weight (150K), virus-specific glycopolypeptide was immunoprecipitated from RSV-infected cell lysate. The antibody response in human sera serially collected from children with primary RSV infection was mainly directed against the polypeptides 30K, 48K, and 72K. The immune response against the other viral proteins was also already detectable in the acute-phase sera. These results indicate that the immune response in RSV infection differs significantly from those for other diseases caused by paramyxoviruses.

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