Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species | Zendy

Jacqueline Deschamps | Zendy; R. Kettmann | Zendy; Arsène Burny | Zendy

Open Access

Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species

Author(s) -

Jacqueline Deschamps,

R. Kettmann,

Arsène Burny

Publication year - 1981

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.40.2.605-609.1981

Subject(s) - bovine leukemia virus , provirus , biology , virology , long terminal repeat , virus , vector (molecular biology) , genome , feline leukemia virus , murine leukemia virus , microbiology and biotechnology , leukemia , dna , restriction enzyme , endogenous retrovirus , genetics , recombinant dna , gene

Taking advantage of the existence of a unique SacI restriction site in the long terminal repeats of the integrated bovine leukemia virus proviral DNA isolated from a bovine tumor, the total viral information (about 9.2 kilobases) was cloned in the lambdoid vector lambda WES. lambda B. Use of this cloned bovine leukemia virus DNA allowed us, for the first time, to definitely rule out the existence of any endogenous bovine leukemia virus sequence in the bovine, ovine, caprine, murine, feline, chicken, or human genomes. These data prove the absence of acquired cellular information in the provirus that has given rise to a tumor.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research