Anatomy of herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis | Zendy

M. L. Fenwick | Zendy; Lawrence S. Morse | Zendy; Bernard Roizman | Zendy

Open Access

Anatomy of herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis

Author(s) -

M. L. Fenwick,

Lawrence S. Morse,

Bernard Roizman

Publication year - 1979

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.29.2.825-827.1979

Subject(s) - biology , herpes simplex virus , dna , gene , single stranded binding protein , virology , virus , microbiology and biotechnology , herpesviridae , dna synthesis , host (biology) , simplexvirus , protein biosynthesis , genetics , dna binding protein , viral disease , transcription factor

Herpes simplex virus type 2 (HSV-2) strains inhibit the synthesis of both DNA and protein of the host cell more rapidly than HSV-1 strains. Several intertypic HSV-1 X HSV-2 recombinants and parental strains were examined for their ability to inhibit rapidly the synthesis of host protein and DNA. The two functions cosegregated in all of eight recombinants tested and are therefore controlled by the same gene or by different genes in the same region of the viral DNA.

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