Replication-defective ecotropic murine leukemia viruses: Detection and quantitation of infectivity using helper-dependent XC plaque formation | Zendy

Alan Rein | Zendy; Robert H. Bassin | Zendy

Open Access

Replication-defective ecotropic murine leukemia viruses: Detection and quantitation of infectivity using helper-dependent XC plaque formation

Author(s) -

Alan Rein,

Robert H. Bassin

Publication year - 1978

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.28.2.656-660.1978

Subject(s) - biology , infectivity , murine leukemia virus , virology , leukemia , virus quantification , viral replication , virus , replication (statistics) , microbiology and biotechnology , genetics

Clones 8A and NP-N, which appear to be infected with replication-defective variants of murine leukemia virus, produce particles which do not form plques in the XC test. These particles formed XC plaques when amphotropic murine leukemia virus, which is XC negative, was added to the assay plates. This phenomenon can be used as a quantitiative infectivity assay for these replication-defective murine leukemia viruses.

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