Open AccessCAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model
Author(s) -
Hiroyuki Matsui,
Kotaro Shirakawa,
Yoshinobu Konishi,
Shigeki Hirabayashi,
Anamaria Daniela Sarca,
Hirofumi Fukuda,
Ryosuke Nomura,
Emani Stanford,
Yoshihito Horisawa,
Yasuhiro Kazuma,
Tadahiko Matsumoto,
Hiroyuki Yamazaki,
Yuji Murakawa,
Emilie Battivelli,
Eric Verdin,
Yoshio Koyanagi,
Akifumi TakaoriKondo
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02394-20
Subject(s) - jurkat cells , biology , human immunodeficiency virus (hiv) , cage , virology , microbiology and biotechnology , t cell , computational biology , immunology , immune system , mathematics , combinatorics
Latent HIV-1 infection is established as early as the first viral exposure and remains the most important barrier in obtaining the cure for HIV-1 infection. Here, we used cap analysis of gene expression (CAGE) to compare the transcriptional landscape of latently infected cells with that of noninfected or productively infected cells.