The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm | Zendy

Xiao Han | Zendy; Marian J. Killip | Zendy; Peter Staeheli | Zendy; Richard E. Randall | Zendy; David J. Jackson | Zendy

Open Access

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

Author(s) -

Xiao Han,

Marian J. Killip,

Peter Staeheli,

Richard E. Randall,

David J. Jackson

Publication year - 2013

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02220-13

Subject(s) - biology , virology , interferon , viral replication , influenza a virus , virus , viral interference , genome , orthomyxoviridae , antiviral protein , viral entry , viral shedding , viral infection , gene , rna , genetics

The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.

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