Open AccessUsing Wolbachia to Eliminate Dengue: Will the Virus Fight Back?
Author(s) -
Kathryn M. Edenborough,
Heather A. Flores,
Cameron P. Simmons,
Johanna E. Fraser
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02203-20
Subject(s) - wolbachia , biology , dengue fever , virology , dengue virus , aedes aegypti , virus , host (biology) , genetics , ecology , larva
Recent field trials have demonstrated that dengue incidence can be substantially reduced by introgressing strains of the endosymbiotic bacteriumWolbachia intoAedes aegypti mosquito populations. This strategy relies onWolbachia reducing the susceptibility ofAe. aegypti to disseminated infection by positive-sense RNA viruses like dengue.