Open AccessEvaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice
Author(s) -
Ting Y. Wong,
Alexander M. Horspool,
Brynnan P. Russ,
Chengjin Ye,
Katherine S Lee,
Michael T. Winters,
Justin R. Bevere,
Olivia A. Miller,
Nathaniel A. Rader,
Melissa Cooper,
Theodore Kieffer,
Julien Sourimant,
Alexander L. Greninger,
Richard K. Plemper,
James Denvir,
Holly A. Cyphert,
Mariette Barbier,
Jordi B. Torrelles,
Iván Martínez,
Luis Martínez-Sobrido,
F. Heath Damron
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02184-21
Subject(s) - virology , biology , genetically modified mouse , antibody , pandemic , immune system , polyclonal antibodies , immunology , alpha (finance) , beta (programming language) , transgene , monoclonal antibody , disease , covid-19 , medicine , infectious disease (medical specialty) , gene , genetics , construct validity , nursing , patient satisfaction , computer science , programming language
Emerging SARS-CoV-2 VoC are posing new problems regarding vaccine and monoclonal antibody efficacy. To better understand immune evasion tactics of the VoC, we utilized passive immunization to study the effect of early-pandemic SARS-CoV-2 HCP against, Alpha, Beta, and Delta VoC.