Open AccessThe Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis
Author(s) -
Benjamin E. Nilsson-Payant,
Benjamin R. tenOever,
Aartjan J.W. te Velthuis
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02092-21
Subject(s) - biology , virology , polymerase , viral replication , rna , rna dependent rna polymerase , nucleoprotein , ribonucleoprotein , rna polymerase , orthomyxoviridae , influenza a virus , virus , genetics , gene
Zoonotic avian influenza A viruses pose a constant threat to global health, and they have the potential to cause pandemics. Species variations in host factor ANP32A play a key role in supporting the activity of avian influenza A virus RNA polymerases in mammalian hosts.