Open Accessp53 Ubiquitination Comediated by HUWE1 and TRAF6 Contributes to White Spot Syndrome Virus Infection in Crustacean
Author(s) -
Yi Gong,
Tongtong Kong,
Jude Juventus Aweya,
Hongyu Ma,
Yueling Zhang,
Shengkang Li
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02029-21
Subject(s) - ubiquitin , ubiquitin ligase , biology , mdm2 , white spot syndrome , scylla paramamosain , microbiology and biotechnology , deubiquitinating enzyme , virus , virology , genetics , apoptosis , gene
p53, which is a well-known tumor suppressor that has been widely studied in higher animals, has been reported to be tightly controlled at low levels by ubiquitin-dependent proteasomal degradation. However, recent p53 ubiquitination-relevant research mainly involved an individual E3 ubiquitin ligase, but not whether there exist other mechanisms that need to be explored.