Open AccessTargeted Deletion of Glycoprotein B Gene by CRISPR/Cas9 Nuclease Inhibits Gallid herpesvirus Type 3 in Dually Infected Marek’s Disease Virus-Transformed Lymphoblastoid Cell Line MSB-1
Author(s) -
Yaoyao Zhang,
Weicheng Li,
Na Tang,
Katy Moffat,
Venugopal Nair,
Yongxiu Yao
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02027-21
Subject(s) - marek's disease , biology , virology , virus , gene , pseudorabies , equine herpesvirus 1 , microbiology and biotechnology , herpesviridae , genetics , viral disease
Marek’s disease (MD) is a lymphoproliferative disease of chickens characterized by rapid-onset lymphomas in multiple organs and by infiltration into peripheral nerves, causing paralysis. Lymphoblastoid cell lines (LCL) derived from MD lymphomas have served as valuable resources to improve understanding of distinct aspects of virus-host interactions in transformed cells including transformation, latency, and reactivation.