Open AccessBirnaviridae Virus Factories Show Features of Liquid-Liquid Phase Separation and Are Distinct from Paracrystalline Arrays of Virions Observed by Electron Microscopy
Author(s) -
Vishwanatha R. A. P. Reddy,
Elle A. Campbell,
Joanna Wells,
Jennifer Simpson,
Salik Nazki,
Philippa C. Hawes,
Andrew J. Broadbent
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02024-21
Subject(s) - biology , transmission electron microscopy , biophysics , capsid , paracrystalline , cytoplasm , electron microscope , virus , colocalization , negative stain , rna , microbiology and biotechnology , virology , materials science , crystallography , biochemistry , chemistry , gene , optics , nanotechnology , physics
Members of theBirnaviridae infect birds, fish and insects, and are responsible for diseases of significant economic importance to the poultry industry and aquaculture. Despite their importance, how they replicate in cells remains poorly understood.