Open AccessInfluenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response
Author(s) -
Mahamud-ur Rashid,
Ang Gao,
Kevin M. Coombs
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01990-21
Subject(s) - biology , microbiology and biotechnology , influenza a virus , viral replication , signal transduction , oxidative stress , proteasome , transcription factor , gene knockdown , immunology , virus , cell culture , biochemistry , genetics , gene
Influenza A virus (IAV) remains one of the most significant infectious agents, responsible for 3 million to 5 million illnesses each year and more than 50 million deaths during the 20th century. The cellular processes that promote and inhibit IAV infection and pathogenesis remain only partially understood.