Open AccessThe C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a
Author(s) -
Hana Veler,
H. Fan,
J.R. Keown,
Jane Sharps,
Marjorie Fournier,
J.M. Grimes,
Ervin Fodor
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01979-21
Subject(s) - biology , polymerase , ribonucleoprotein , microbiology and biotechnology , rna polymerase , rna polymerase ii , small nuclear rna , influenza a virus , rna dependent rna polymerase , rna polymerase i , nuclear transport , orthomyxoviridae , rna , virology , cytoplasm , cell nucleus , biochemistry , virus , gene , gene expression , promoter
The influenza virus RNA genome segments are replicated in the cell nucleus and are assembled into viral ribonucleoprotein (vRNP) complexes with viral RNA polymerase and nucleoprotein (NP). Replicated vRNPs need to be exported from the nucleus and trafficked across the cytoplasm to the cell membrane, where virion assembly takes place.