Open AccessImpact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells
Author(s) -
Sachiko Hirose,
Mihoko Kato,
Kati Tormanen,
Pedram Shafiei Jahani,
Omid Akbari,
Homayon Ghiasi
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01934-20
Subject(s) - innate lymphoid cell , biology , immunology , neuroimmunology , central nervous system , cytokine , lymphatic system , microbiology and biotechnology , innate immune system , neuroscience , immune system
Innate lymphocytes have plasticity and can change functionality; type 2 innate lymphoid cells (ILC2s) can convert to ILC1 or ILC3 cells or change their activation state to produce IL-17 or IL-10 depending on environmental cues. In this study, we investigated the gene and cytokine profiles of ILC2s, which play a major role in HSV-IL-2-induced CNS demyelination.