Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells | Zendy

Satoshi Hirose | Zendy; Mihoko Kato | Zendy; Kati Tormanen | Zendy; Pedram Shafiei-Jahani | Zendy; Omid Akbari | Zendy; Homayon Ghiasi | Zendy

Open Access

Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells

Author(s) -

Satoshi Hirose,

Mihoko Kato,

Kati Tormanen,

Pedram Shafiei-Jahani,

Omid Akbari,

Homayon Ghiasi

Publication year - 2020

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01934-20

Subject(s) - innate lymphoid cell , biology , immunology , microbiology and biotechnology , central nervous system , gene , cytokine , neuroimmunology , lymphatic system , innate immune system , neuroscience , immune system , genetics

Innate lymphocytes have plasticity and can change functionality; type 2 innate lymphoid cells (ILC2s) can convert to ILC1 or ILC3 cells or change their activation state to produce IL-17 or IL-10 depending on environmental cues. In this study, we investigated the gene and cytokine profiles of ILC2s, which play a major role in HSV-IL-2-induced CNS demyelination.

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